Dr.Ruhul H Kuddus

Assistant Professor
Biology

Ruhul H Kuddus has been at UVSC since 2003.

EDUCATION AND TRAINING

Ph.D. Molecular Genetics and Biochemistry, University of Pittsburgh , Pittsburgh, Pennsylvania, USA

M.S. Biology, George Mason University , Fairfax, Virginia, USA

B.Sc. (Biology and Chemistry), and M.Sc. (Zoology) with Distinctions, University of Dhaka , Dhaka, Bangladesh

HONORS AND AWARDS

Faculty Scholar of the Year (2007), Utah Valley State College, Orem , Utah, USA

Scholar in Residence (2006-2007), American Society for Microbiology, Washington DC, USA

Dean’s Scholar (1988-1989), University of Pittsburgh , Pittsburgh, Pennsylvania, USA

University Merit Scholar (1977-1979), University of Dhaka , Dhaka, Bangladesh

PUBLICATIONS (Research Articles)

Kuddus R., DeLuca N. DNA dependent oligomerization of HSV-1 regulatory protein ICP4. J Virol 2007 September; 81: 9230-9237. http://jvi.asm.org/cgi/content/full/81/17/9230.
Islam F, Gooch R, Wilson I, Kuddus R. Sustainable Development: Reflection on Some Asian Countries. J Utah Acad Sci 2006; 83:52-63.

Kuddus, R. Ginkgo biloba Medications: Prospects and Some Supplemental Problems. J Utah Acad Sci 2005; 82:41-50.

Kuddus RH, Metes DM, Nalesnik MA, Logar AJ, Rao AS, Fung JJ. "Porcine cell microchimerism but lack of productive porcine endogenous retrovirus infection in naive and humanized SCID-beige mice treated with porcine peripheral blood mononuclear cells." Transpl Immunol. 2004 Jun-Jul;13(1):15-24.

Kuddus RH, Lee Y-H, Valdivia LA. "A semiquantitative PCR technique for detecting chimerism in hamster to rat bone marrow xenotransplantation." J Immunol Methods 2004 Feb 15;285(2):245-51.

Kuddus RH, Gandhi CR, Rehman KK, Guo F, Watkins SC, Valdivia LA, Fung JJ. "Some morphological, growth, and genomic properties of human cells chronically infected with porcine endogenous retrovirus (PERV)." Genome 2003 Oct; 46(5): 858-869.

Kuddus R, Patzer II JF, Lopez R, Mazariegos G, Meighen B, Kramer DJ, Rao AS. "Clinical and laboratory evaluation of a bioartificial liver assist device for potential transmission of porcine endogenous retrovirus." Transplantation 2002; 73:420-429.

Kuddus R, Kuddus N, Dvorchick I. "DNA polymorphism in the living fossil Ginkgo biloba from the Eastern United States." Genome 2002; 45:8-12.

Sun H, Woodward JE, Subbotin VS, Kuddus R, Logar A, Schaefer AT, Aitouche A, Rao AS. "The use of recombinase activation gene-2 deficient mice to ascertain the role of cellular and humoral immune response in the development of chronic rejection." J Heart Lung Transplant 2002; 21:738-750.

Kuddus R, Patzer JF, Lopez R, Mazariegos GV, Meighen B, Kramer DJ, Fung JJ, Rao AS. "Valuation of transmission of porcine endogenous retrovirus into patients subjected to hemoperfusion using an extracorporeal bioartificial liver support system." Transplant Proc 2001; 33:1976.

Rao AS, Dvorchik I, Dodson F, Abu-Elmagd K, Schaefer AT, Ostrowski L, Valenti M, Zeevi A, Kuddus R, Starzl TE, Fung JJ. "Donor bone marrow infusion in liver recipients: Effect on the occurrence of acute cellular rejection." Transplant Proc 2001; 33:1352.

Gandhi CR, Kuddus RH, Nemoto EM, Murase N. "Endotoxin treatment causes an upregulation of the endothelin system in the liver: Amelioration of increased portal resistance by endothelin receptor antagonism." J Gastroenterol Hepatol 2001; 16:61-9.

Kuddus RH, Nalesnik MA, Subbotin VM, Rao AS, Gandhi CR. "Enhanced synthesis and reduced metabolism of endothelin-1 (ET-1) by hepatocytes--An important mechanism of increased endogenous levels of ET-1 in liver cirrhosis." J Hepatol 2000; 33:725-32.

Gandhi CR, Kuddus RH, Uemura T, Rao AS. "Endothelin stimulates transforming growth factor-�1 and collagen synthesis in stellate cells from control but not cirrhotic rat liver." Eur J Pharmacol 2000; 406:311-8.

Cicalese L, Kuddus R, Yacoub W, Subbotin V, Fung JJ, Starzl TE. "Ischemia/reperfusion injury induces chronic changes in the small bowel." Transplant Proc 2000; 32:1315.

Gandhi CR, Uemura T, Kuddus R. "Endotoxin causes up-regulation of endothelin receptors in cultured hepatic stellate cells via nitric oxide-dependent and -independent mechanisms." Br J Pharmacol 2000; 131:319-27.

Miki T, Lee YH, Tandin A, Subbotin V, Kuddus R, Rao AS, Fung JJ, Starzl TE, Valdivia LA. "Xenogeneic humoral graft-vs-host disease following hamster-to-rat bone marrow transplantation." Transplant Proc 2000; 32:1036-7.

Lee YH, Miki T, Kuddus R, Tandin A, Goller AL, Subbotin V, Fung JJ, Peach R, Valdivia LA, Rao AS. "Administration of CTLA4-Ig enhances the incidence of hamster-to-rat xenogeneic bone marrow engraftment and alters the presentation of graft-vs-host disease." Transplant Proc 2000; 32:1032-3.

Gandhi CR, Kuddus R, Subbotin VM, Prelich J, Murase N, Rao AS, Nalesnik MA, Watkins SC, DeLeo A, Trucco M, Starzl TE. "A fresh look at augmenter of liver regeneration in rats." Hepatology 1999; 29:1435-45.

Gabriel A, Kuddus RH, Rao AS, Gandhi CR. "Down-regulation of endothelin receptors by transforming growth factor beta1 in hepatic stellate cells." J Hepatol 1999; 30:440-50.

Rastellini C, Salam A, Kuddus R, Aitouche A, Subbotin V, Braun M, Leach R, Peach R, Fung JJ, Starzl TE, Rao AS. "Prevention of T-cell activation by rhCTLA4-Ig and anti-CD40L monoclonal antibody results in indefinite islet allograft survival." Transplant Proc 1999; 31:1242-3.

Salam A, Aitouche A, Kuddus R, Peach R, Fung JJ, Rao AS. "The combined use of sublethal irradiation and costimulatory blockade to generate mixed bone marrow chimeras." Transplant Proc 1999; 31:1197-8.

Cicalese L, Yacoub W, Subbotin V, Kuddus R, Fung JJ, Stanko R, Rao AS. "Pyruvate inhibits the chronic damage which ensues after ischemia/reperfusion injury of kidneys." Transplant Proc 1999; 31:1033.

Rastellini C, Salam A, Kuddus R, Aitouche A, Braun M, Leach R, Peach R, Fung JJ, Starzl TE, Rao AS. "Mechanisms underlying the development of T-cell tolerance following interruption of signaling at the CD28/B7 and CD40/gp39 interface." Transplant Proc 1999; 31:845.

Gabriel A, Kuddus RH, Rao AS, Watkins WD, Gandhi CR. "Superoxide-induced changes in endothelin (ET) receptors in hepatic stellate cells." J Hepatol 1998; 29:614-27.

Kuddus R, Gu B, DeLuca NA. "Relationship between TATA-binding protein and herpes simplex virus type 1 ICP4 DNA-binding sites in complex formation and repression of transcription." J Virol 1995; 69:5568-75.

Gu B, Kuddus R, DeLuca NA. "Repression of activator-mediated transcription by herpes simplex virus ICP4 via a mechanism involving interactions with the basal transcription factors TATA-binding protein and TFIIB." Mol Cell Biol 1995; 15:3618-26.

Kuddus R, Schmidt MC. "Effect of the non-conserved N-terminus on the DNA binding activity of the yeast TATA binding protein." Nucleic Acids Res 1993; 21:1789-96.

Kuddus R, Quddus MMA, Shafi M. "Length frequency distribution and fishery of shingfish, Heteropneustes fossilis, Bloch." Bangladesh J Zool 1997; 16:74-79.

Kuddus R, Quddus MMA, Shafi M. "Feeding and breeding habits of shingfish, Heteropneustes fossilis (Bloch)." Dhaka Univ J Biol Sci 1996; 5:32-43.

Kuddus, R. (1984) "Length-weight relationship and condition factor in the catfish Heteropneustes fossilis (Bloch)." Bangladesh J Zool 1981; 12:49-52.

Books and book chapters

Butterfield T, Kuddus R. Organ Sale and Theft, A Reality Check with an Ethical Perspective. Ethics in Professions, McDonald R, Yells D (Ed.), Orem, UVSC Printing (2007).

Kudus R, Oakes J, Kopp O. Globalization and international molecular biotechnology transfer: ethical, technological and organizational issues. Keller D ed. Spheres of Globalization, Orem, Utah , UVSC Printing (2006)

Ali A, Kuddus RH, Andaleeb SS. (2004). Development Issues of Bangladesh II, Dhaka, University Press Limited, 579 pp.

Kuddus, R. "Fisheries, aquaculture and water resources of ." Ali A, Kuddus RH, Andaleeb, S.S. eds. Development Issues of II. Dhaka : University Press, 2003.

Ali, A, Islam MF, Kuddus R. (1996). Development Issues of Bangladesh, Dhaka, University Press Limited, 409 pp.

Kuddus RH. Technology transfer and Biorevolution in the Third World, In Development Issues of Bangladesh, Ali A, Islam MF, Kuddus RH, eds. Dhaka: University Press Limited, pp 335-358.

Other publications

Buuterfield T, (Adviser: Kuddus R). Solid organ theft: An investigation on the reality and implications. Proc Nat Conf Undergrad Res 2007, 21:886-891.

Abstracts/Presentation

Kuddus R. How Microquestioning Approach of Teaching Affects Student Learning and Learning Strategies, American Society for Microbiology Conference for Undergraduate Educators 2007, Buffalo New York ; (May 2007)

Butterfield T, Kuddus R. Organ sale and theft: An investigation on reality and implications, NCUR annual conference, San Rafael, CA (April 2007)

Islam F, McAdams-Jones D, Kuddus R. Human organ procurement for transplantation: Revisiting incentives. Utah Academy of Arts, Sciences and Letters Annual Conference, Cedar City UT (April 2007)

Toruno C, Kuddus R. Expression and partial characterization a recombinant protein product of a primate-specific ORF, American Society for Microbiology, Intermountain Conference 2007, Pocatello, ID (March 2007).

Scott J, Oakes J, Slater K, Kirsi J, Kuddus R. Bacterial contamination of CAM derived from Ginkgo biloba. American Society for Microbiology, Intermountain Conference 2007, Pocatello, ID (March 2007)

Butterfield T, Kuddus R. Organ Sale and Theft: A reality check with an ethical perspective. Professional Ethics Conference 2006, UVSC, Orem UT (December 2006)

Toruno C, Kuddus R. Expression of Rat and Human Augmenter of Liver Regeneration (ALR) in Bacteria. UCUR 2007, Slat Lake City, UT (January 2007)

Toruno C, Kuddus R. Ethical constraints in Xenotransplantation, Ethics Across the Curriculum Conference of UVSC, Orem UT (October 2006)

Kuddus R, Isolation of fungi from Ginkgo biloba leaves and herbal supplement, ASM National Conference, Orlando FL 2006 (poster presentation)

Toruno C, Kopp O, Kuddus R. Ethical problems in xenotransplantation. Center for Study of Ethics Conference, Orem , UT 2006 (oral presentation)

Islam F, Gooch R, Kuddus R. Theory of Sustainable Development: Application to Some Asian Countries. Annual Conference of the Utah Academy of Science, Ephraim, UT 2006 (oral presentation).

Walker D, Kuddus R. An outside shot at unraveling the mysteries of Waldenström’s Macroglobulinemia, NCUR Annual National Conference 2006 (oral presentation).

Oakes J, Kuddus R. In search of a fast growing halophyle from The Great Slat Lake: A heavily polluted natural environment. NCUR National Conference 2006 (poster presentation).

Oakes J, Kuddus R. Characterization of two halophiles isolated from the Great Slat Lake , ASM Intermountain Regional Conference 2006 (oral presentation)

Oakes J, Kopp O, Kuddus R. Globalization of Biotechnology, Center for Study of Ethics Conference, Orem, UT 2005 (oral presentation)

Kuddus, R. Ginkgo biloba: Supplemental problems (and prospects), Utah Academy of Arts, Science and Letters, Annual Conference, Orem, UT (May 2005)

Oakes J, Moss T, Christianson JT, Stargill B, Slater K. and Kuddus R. Probing Microbial Diversity by RFLP Analysis of PCR-amplified small subunit rDNA Fragments. American Society for Microbiology Intermountain Regional Conference, Ogden, UT (April, 2005).

Sharp C, Burt W. Kopp O, Slater K, Kirsi J, Kuddus R. Isolation of Pathogenic Fungi from Healthy Ginkgo biloba Leaves and Ginkgo Herbal Preparations Sold in Health Food Stores. American Society for Microbiology Intermountain Regional Conference, Ogden, UT (April, 2005)

Glazier R, Morris C, Prelich J, Kuddus R. Expression of Rat and Human Augmenter of Liver Regeneration (ALR) in Bacteria. American Society for Microbiology Intermountain Regional Conference, Ogden, UT (April, 2005)

Sharp C, Kuddus R. Fungal infection of Ginkgo biloba. National Conference for Undergraduate Research, Lexington, Virginia (April 2005)

Kuddus R. Lack of release of infectious retroviral particles by reverse-trasncriptase positive primary porcine cells. Intermountain Branch Meeting, American Society for Microbiology, Idaho Falls, Idaho , March 2004.

Kirsi J, Kopp O, Burt W, Bracken M, Slater K, Robbins RR, Van Buren R, Kuddus R. Fungal blight of the living fossil Ginkgo biloba. Intermountain Branch Meeting, American Society for Microbiology, Idaho Falls, Idaho , March 2004.

Kuddus R, Nalesnik MA, Metes D, Gandhi C, Fung JJ. Infection of immunodeficient (SCID-beige) mice with porcine endogenous retrovirus. XIX International Congress of the Transplantation Society, Miami, FL , August 2003.

Kuddus R, Patzer JF, Fung JJ. Expression of porcine endogenous retrovirus genes in hepatocytes isolated from specific pathogen-free pigs for loading bioreactors used in a bioartificial liver support system. McGowan Institute for Regenerative Medicine Scientific Retreat and Strategic Planning Session, Nemacolin Woodlands, PA, February 2002.

Kuddus R, Rao AS , Nalesnik M, Fung JJ. Transmission of porcine endogenous retrovirus (PERV) in vivo to SCID-beige mice receiving porcine or porcine and human peripheral blood mononuclear cells. International Xenotransplantation Association Congress (IXA2001), Chicago, IL , September 2001.

Kuddus R, Tarara, M, Rao AS. Interspecies transmission of porcine endogenous retrovirus in vivo. Transplantation 2001 Joint Meeting, Chicago, IL , May 2001.

Kuddus R, Rao AS. Interspecific transmission of porcine endogenous retrovirus through cellular transplantation. Festschrift honoring Thomas E. Starzl, Pittsburgh, PA , April 2001.

Uemura T, Chi X, Kuddus R, Gandhi, CR. Stellate cells produce hepatic growth inhibitory factor(s) other than TGF-b, IL -6, IL-1b, and TNF-a upon stimulation with endotoxin. Festschrift honoring Thomas E. Starzl, Pittsburgh, PA , April 2001.

Kuddus R, Patzer II JF, Lopez R, Mazariegos GV, Meighen B, Kramer DJ, Fung JJ, Rao AS. Evaluation of transmission of porcine endogenous retrovirus (PERV) into patients subjected to hemoperfusion using an extracorporeal bioartificial liver support system. XVIII International Congress of the Transplantation Society, Rome, , August 2000.

Kuddus RH, Patzer II JF, Mazariegos GV, Kramer DJ, Fung JJ, Rao AS. No evidence of transmission of porcine endogenous retrovirus (PERV) into patients with end-stage liver failure subjected to hemoperfusion using an extracorporeal bioartificial liver support system (BLSS). Transplantation 2000 Joint Meeting, Chicago IL , May 2000.

Gandhi, CR, Uemura T, Kuddus R. Endotoxin causes up-regulation of endothelin receptors in hepatic stellate cells via nitric oxide-dependent and –independent mechanisms. AASLD 51^st Annual Meeting and Graduate Course, Dallas, TX , October 2000.

Uemura T, Chi X, Kuddus R, Gandhi CR. Inhibition of DNA synthesis by endotoxin conditioned stellate cell medium is not mediated by via nitric oxide or transforming growth factor-b. AASLD 51^st Annual Meeting and Graduate Course, Dallas, TX , October 2000.

Kuddus R, Daskivich T, Sun H, Subbotin V, Aitouche A, Lee YH, Valdivia L, Fung JJ, Rao AS. The temporal relationship between the cellular and humoral immune responses in the pathogenesis of transplant vascular sclerosis. ASTS, Chicago, IL , May 1999.

Kuddus R, Gandhi CR, Subbotin VS, Prelich J, Murase N, Rao AS, Nalesnik MA, Watkins S, DeLeo A, Starzl TE. Changes in hepatic and circulating levels of augmenter of liver regeneration (ALR) after partial hepatectomy: Alteration in ALR conformation may be a mechanism of its activation. ILTS Fifth Congress, Pittsburgh, PA , August 1999.

Gandhi CR, Gabriel A, Kuddus RH, Watkins S, Rao AS, Nemoto EM. Mechanism of endothelin mediated portal hypertension: Amelioration by endothelin receptor antagonism. ILTS Fifth Congress, Pittsburgh, PA , August 1999.

Gabriel A, Kuddus RH, Rao AS, Gandhi CR. Transforming growth factor-b1-induced decrease in endothelin receptors and function in hepatic stellate cells: A compensatory mechanism in liver cirrhosis. ILTS Fifth Congress, Pittsburgh, PA , August 1999.

Kuddus R, Rojers J, Dodson F, Valdivia LA, Zeevi A, Fung JJ, Starzl TE, Rao AS. Evidence for long-term persistence of donor cell chimerism after baboon to neonatal pig bone marrow xenotransplantation. XVII World Congress of the Transplantation Society, Montreal, Quebec, , July 1998.

Salam A, Kuddus RH, Rao AS. Creation of mixed bone marrow chimeras by sublethal irradiation and combined blockade of CD28/B7and CD40/CD40L costimulatory pathways. 5th International Symposium on Dendritic Cells in Fundamental and Clinical Immunology, Pittsburgh, PA , September 1998.

Metes D, Rowe DT, Gambotto A, Zeevi A, Storkus W, Robbins P, Olson W, Ranieri E, Wilson C, Herr W, Kuddus R, Rao A, Fung JJ, Nalesnik MA. Response of T lymphocytes to dendritic cells infected with recombinant adenovirus expressing the Epstein-Barr virus latency protein LMP2: A preliminary report. 5th International Symposium on Dendritic Cells in Fundamental and Clinical Immunology, Pittsburgh, PA , September 1998.

Salam A, Aitouche A, Kuddus RH, Rao AS. Creation of mixed bone marrow chimera by sublethal irradiation and combined blockade of CD28/B7 and CD40/CD40L costimulatory pathways. ASTP, Chicago, IL , May 1998.

Gandhi CR, Subbotin VS, Kuddus RH, Prelich J, Rao AS, DeLeo A, Nalesnik MA, Starzl TE. Immunohistochemical localiztion of the augmenter of liver regeneration in the cytosol of adult rat liver hepatocytes. Annual Meeting of the American Society for Biochemistry and Molecular Biology and ASMB Satellite Meeting, Bethesda, MD, August 1998.

Gandhi CR, Gabriel A, Kuddus RH, Rao AS. Superoxide-mediated up-regulation of endothelin (ET) receptors in myofibroblastic stellate cells: A mechanism of portal hypertension. Vascular Biology ‘98, San Francisco, CA , April 1998.

Kuddus R, DeLuca NA. DNA dependent oligomerization of HSV1 ICP4. 21st International Herpes Virus Workshop, Dekalb, IL , July 1996.

Gu B, Kuddus R, DeLuca NA. Repression of activator mediated transcription by HSV ICP4 via a mechanism involving complex formation with TBP and TFIIB. 20th International Herpes Virus Workshop, Croningen, The , June 1995.

Kuddus R, Ansari RA. Problems of recombinant-DNA based biotechnology transfer to the developing countries. Socio-Economic Development of Conference, Pittsburgh, PA , August 1995.

Milcarek CA, Lassman CR, Hall B, Matis S, Kuddus R, Toppmeyer D. Sequence downstream of the immunoglobulin gamma 2b secretion specific polyA site confer plasma cell type regulated expression. RNA Processing Meeting, Cold Spring Harbor, NY , June 1991.

PROFESSIONAL RESEARCH ACTIVITIES (GRANTS)

Pending: Major Research Instrumentation for Genomics and Proetomics Research at UVSC

Ongoing:

UVSC Presidential Research Award (2003, 2004, 2005, 2006 and 2007)
Grant Title: Undergraduate Ressearch Initiatives
Role: Principal Investigator

UVSC Foundation Award (2004, 2007)

Grant Title: Instrumentation forTissue Culture facility At UVSC

Role: Principal Investigator

Completed:

VA Merit Award (2000-2003)
Grant Title: Roles of Augmenter of Liver Regeneration (ALR) in Liver Regeneration
Role: Co-investigator

National Institute of Health grant DK29961-18 (1996-2001)
Grant Title: Orthotopic Liver Transplantation in Human
Role: Co-investigator

National Institutes of Health Grant 3: R01A40329-05 (1996-2001)
Grant Title: Combined Bone Marrow and Organ Transplantation in human
Role: Co-investigator

CURRENT RESEARCH INTERESTS

Biology of Porcine Endogenous Retrovirus
Proteomics of transcribed open reading frames of unknown functions
Fungal colonization of medicinal plants